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Calculating My Odds – PCOS (Polycystic Ovarian Syndrome)

Chance for Pregnancy with and without Clear Passage®

There is no substitute for published facts.

If you are serious about reversing your infertility, there is no substitute for reliable data published in peer-reviewed medical journals. The studies cited in these pages are indexed in PubMed, the ‘gold standard’ search engine maintained by the U.S. National Institutes of Health (NIH).

Additional data comes from the U.S. Centers for Disease Control (CDC) database of success rates for U.S. reproductive clinics. To allow time for live births and data collection, the CDC report shows results of procedures performed 2 to 3 years prior.

Published Pregnancy Rates Treating
PCOS Related Infertility

  • Clear Passage                                               53.57%
  • Ovarian Drilling surgery                           20-64%
  • Ovarian Wedge surgery                                  78%
  • Clear Passage®, then IVF                         56.16%
  • IVF alone:                                                      24.11%[i]

Details

Pregnancy Rates using Clear Passage                               53.57%

The overall pregnancy success rate was 53.57% (15/28); one of the 15 pregnancies in this data subset was achieved via IVF, the rest were natural pregnancies.

Pregnancy Rates after Ovarian Drilling                           20-64%

A comprehensive review of ovarian drilling for PCOS[xii] concluded that ovarian drilling leads to spontaneous restoration of fertility in 20–64%.

Pregnancy Rates after Ovarian Wedge surgery                  78%

Follow-up study of 149 patients showed a cumulated live birth rate of 78%, with estimates that 69.5% would develop post-operative adhesions.[xiii]

Pregnancy Rates for Clear Passage®, then IVF              56.16%

The 56.16% figure reflects the overall success rate for all ages. Individual age groups are shown in a table below using data from the CDC and a published study[ii] that examines Clear Passage® rates.

The table below compares pregnancy rates after embryo transfer for IVF with and without a course of our therapy given within 15 months before starting an IVF cycle. Simply view your age group in the table below to understand our “combined rate” for IVF following Clear Passage® therapy.

Calculated by an independent biostatistician, these results show a very high statistical significance (credibility) in all age categories. This data gives a very good picture of the advantage of using Clear Passage® therapy before IVF.

IVF Pregnancy Rates With & Without Clear Passage®

Age Group Rate with CP Therapy Rate without CP Therapy Statistical p-value
Under 35 68% 45% 0.0067
35-37 60% 37% 0.0133
38-40 49% 29% 0/0107
41-42 54% 19% 0.0039
Over 42 44% 9% <0.0001

Note: all p-values in this chart are statistically significant
Percentages are rounded to whole numbers.

Pregnancy Rates for IVF alone (USA) 24.11%[iii]

Advantages of IVF
Physician monitored
Whether success or failure, results occur quickly
Additional eggs may be saved for future transfers

Disadvantages of IVF
If unsuccessful, attempt must be repeated
Must be repeated for every desired pregnancy
May involve surgery to remove one or both fallopian tubes
Involves pharmaceutical medications some may wish to avoid
Not shown to improve intercourse pain or sexual function

Worldwide IVF Success Rates

Worldwide IVF Success Rates

United States: 24.11%[iv] United Kingdom: 2% to 29%[v]
Japan: ~ 5%[vi] Australia / New Zealand ~10% to 15%vi

Several studies examine worldwide success rates for IVF. Most note a significant decline in pregnancy rates over the last 10 – 12 years[vii] as shown below.

United States IVF rates:

In vitro fertilization (IVF) is often suggested for women with blocked fallopian tubes. Based on CDC’s 2018 Fertility Clinic Success Rates Report, the 306,197 ART cycles performed at 456 reporting clinics in the United States during 2018 resulted in 73,831 live births. Based on the above, CDC shows a 24.11% national success rate for Assisted Reproductive Techniques in the USA, 99% of which are IVF. Some cycles were designed for ‘egg harvesting’ with the intent of using those eggs in later transfers which makes more exact results difficult to tabulate. Thus, we made further inquiry with results shown below.

Worldwide and US Downward Trend in IVF Success:

A 2019 study[viii] of two decades of IVF pregnancy rates showed a downward trend in worldwide and US IVF pregnancy rates starting in 2010. The study notes that US live birth rates for fresh cycle IVF or ICSI reached a high in 2008, plateaued till 2010 and have since steadily declined with profound drops between 2013 and 2016, the last year cited in the study.

ivf downward trend

United Kingdom IVF Rates: 2% to 29%

The British National Health Service (NHS) reports[ix] that between 2014 and 2016 the percentage of IVF treatments that resulted in a live birth was:
29% for women under 35
23% for women aged 35 to 37
15% for women aged 38 to 39
9% for women aged 40 to 42
3% for women aged 43 to 44
2% for women aged over 44

Other countries

IVF rates in Japan and in (combined) Australia and New Zealand cited in the study were:
Japan: ~ 5%[x] Australia / New Zealand: 10%-15%vi

[i] https://www.webmd.com/infertility-and-reproduction/guide/in-vitro-fertilization#3
[ii] Rice AD, Patterson K, Wakefield LB, Reed ED, Breder KP, Wurn BF, King CR and Wurn LJ. (2015a). Ten-year retrospective study on the efficacy of a manual physical therapy to treat female infertility. Alt Ther Health Med, 21(3):32-40.
[iii] https://www.webmd.com/infertility-and-reproduction/guide/in-vitro-fertilization#3
[iv] https://www.cdc.gov/art/artdata/index.html
[v] https://www.nhs.uk/conditions/ivf/ Kushnir VA, Barad DH, Albertini DF, Darmon SK, Gleicher N. Systematic review of worldwide trends in assisted reproduction 2014–2013. Reprod Biol Endocrinol 2017a;15:6.
[vi] Kushnir VA, Barad DH, Albertini DF, Darmon SK, Gleicher N. Systematic review of worldwide trends in assisted reproduction 2014–2013. Reprod Biol Endocrinol 2017a;15:6.
[vii] Gleicher N, Kushnir VA, Barad DH. Worldwide decline of IVF birth rates and its probable causes. Hum Reprod Open. 2019;2019(3):hoz017. Published 2019 Aug 8. doi:10.1093/hropen/hoz017
[viii] Gleicher N, Kushnir VA, Barad DH. Worldwide decline of IVF birth rates and its probable causes. Hum Reprod Open. 2019;2019(3):hoz017. Published 2019 Aug 8. doi:10.1093/hropen/hoz017
[ix] https://www.nhs.uk/conditions/ivf/
[x] Kushnir VA, Barad DH, Albertini DF, Darmon SK, Gleicher N. Systematic review of worldwide trends in assisted reproduction 2014–2013. Reprod Biol Endocrinol 2017a;15:6.
[xi] Liakakos, T., Thomakos, N., Fine, P., Dervenis, C., & Young, R. (2001). Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg, 18(4), 206–273.
[xii] Fernandez H, Morin-Surruca M, Torre A, Faivre E, Deffieux X, Gervaise A. Ovarian drilling for surgical treatment of polycystic ovarian syndrome: a comprehensive review. Reprod Biomed Online. 2011 Jun;22(6):556-68. doi: 10.1016/j.rbmo.2011.03.013. Epub 2011 Mar 21. PMID: 21511534.
[xiii]Lunde O, Djøseland O, Grøttum P. Polycystic ovarian syndrome: a follow-up study on fertility and menstrual pattern in 149 patients 15-25 years after ovarian wedge resection. Hum Reprod. 2001 Jul;16(7):1479-85. doi: 10.1093/humrep/16.7.1479. PMID: 11425833.