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Women’s Health and Fertility Success Rates

Overview

Pregnancy Rates

  • Blocked Fallopian Tubes – 57% pregnancy rate for women whose tubes have opened (vs. 22% – 34% for surgery)
  • Endometriosis – 43% pregnancy rate
  • PCOS – 54% pregnancy rate
  • High FSH – 39% pregnancy rate
  • Pre-IVF – 56% with Clear Passage before transfer (vs. 37% without Clear Passage) (Rice et al., 2015a)

pre-treatment and post-treatment x-rays showing fluid passing through opened fallopian tubes

Blocked Fallopian Tubes (2015, 2008)

success rate for opening blocked fallopian tubes

Pregnancy Rates for Blocked Fallopian Tubes

2015 Study

  • 61% (143/235 patients) success rate opening blocked fallopian tubes
    – Location of the blockage did not influence clearance rates
    – 69%(124/180 patients) success rate opening blocked tubes in which patients had not undergone surgery to open their tubes before CPA treatment
    – 35% (19/55 patients) success rate opening blocked tubes in which patients had undergone surgery to open their tubes before CPA treatment
  • 45% (47/105 patients) clearance of hydrosalpinx
  • 56.3% (81/143 patients) pregnancy rate
    – 80 natural pregnancies; 1 pregnancy via IVF
    – Multiple pregnancies experienced following treatment suggesting long lived (measured in years) for treatment success
  • 60% (40/67 patients) success rate in opening blocked fallopian tubes in women with endometriosis (Rice et al., 2015a)

Success Rates Opening Tubes With and Without Prior Tubal Surgery:

  • 69% patency rate (opened tubes) in women with no prior surgical repair to the tubes
  • 35% patency (opened tubes) in women who have undergone prior tubal repair
  • 61% patency (opened tubes) overall – opening one or both fallopian tubes (Rice et al., 2015a)opening blocked fallopian tubes after tubal surgery

2008 Study

  • 61% (17/28 patients) success rate opening blocked fallopian tubes (there were 28 patients in this study)
    – 66% (8/12 patients) patency (one or both tubes open) rate for patients with proximal blockage
    – 50% (3/6 patients) patency rate for patients with distal blockage
    – 40% (2/5 patients) patency rate for patients with mid-tubal blockage
    – 80% (4/5 patients) patency rate for patients with combination blockage
  • 53% (9/17 patients) natural intrauterine pregnancy rate for the patent patients
  • Hydrosalpinx
    – 50% (4/8 patients) success rate opening tubes blocked with hydrosalpinx
    – 50% (2/4 patent patients) had a natural post-therapy full-term pregnancy via the tube previously blocked with hydrosalpinx (Wurn et al., 2008)

Treating Hormone Related Infertility

PCOS Pregnancy Rates

endometriosis pregnancy rates

2015 Study:

  • 49% (60/122 patients) rate of decreasing FSH levels after treatment
  • 39% (48/122 patients) pregnancy rate in women with high FSH levels after treatment
    – 43 pregnancies by natural conception; 5 pregnancies via IVF
    – 40% (10/25 patients) pregnancy rate in women with both endometriosis and high FSH
  • 20% (1/5 patients) pregnancy rate in patients with POF via natural conception
  • 54% (15/18 patients) pregnancy rate in with PCOS
    – 14 natural conception pregnancies; 1 pregnancy via IVF (Rice et al., 2015a)

2009 Study:

  • 94% (15/16 patients) of women with high FSH before treatment, reported a natural pregnancy or significant decrease in FSH levels after treatment
    – 6 women experienced natural pregnancies (Wurn et al., 2009)

Natural Fertility (2008)

  • 71% (10/14 patients) natural pregnancy rate within one year of receiving therapy (Wurn et al., 2004)natural fertility pregnancy and birth rates

Note: Measured scientifically, our natural fertility success rate is between 47.8% and 73.6% (95% confidence interval). (Wurn et al., 2004a; Wurn et al., 2008)

Pre-IVF Pregnancy Rates (2015, 2004)

2015 Study:

  • 56% (82/146 patients) IVF pregnancy rate for women that underwent treatment before their IVF transfer. This is 1.5 times higher than that of the national average of 37%. (SART 2010 data)
  • 68% (27/40 patients) pregnancy rate in women under 35 years old
  • 52% (49/94 patients) pregnancy rate in women over 35 years old
    – 44% (7/16 patients) IVF pregnancy rate in women 42 or older
    – 54% (7/13 patients) IVF pregnancy rate in women ages 41-42 years old
  • 55% (31/56 patients) pregnancy rate via IVF in women with endometriosis (Rice et al., 2015a)

pre-ivf therapy success rates

2004 Study

  • 67% (22 pregnancies/33 transfers) IVF clinical pregnancy rate for women who received therapy within 15 months of IVF transfer- women in this study demonstrated a pregnancy rate 3 times greater than that of untreated women, per national statistics.
  • 52% live birth rate for the above patients
  • clinical pregnancy and live birth rates in this group include a 43-year-old patient (Wurn et al., 2004a)

Duration of Infertility (2004)

  • Women in our early studies (natural and pre-IVF) were infertile for an average of 4.5 years prior to therapy; the range of reported infertility in this study was 1 to 20 years. (Wurn et al., 2004a)

Live Birth Rates (2004, 2008)

2008 Study:

  • 90% (9/10 patients) of women who became pregnant in the natural fertility study delivered full-term babies
  • 33% (3/9 patients) of these women had a subsequent pregnancy and live birth, suggesting that this treatment can have lasting effects for some women (Wurn et al., 2008)

2004 Study

  • 79% (15/22 patients) of women who became pregnant in the pre-IVF study had live births (Wurn et al., 2004a)

Unexplained Infertility (2015)

  • 25% (3/12 patients) pregnancy rate in patients diagnosed with unexplained infertility
    – 2 natural conception pregnancies; 1 pregnancy via IVF (Rice et al., 2015a)

Advanced Age (2015, 2008, 2004)

2015 Study:

  • 44% (7/16 patients) IVF pregnancy rate in women 42 or older
  • 54% (7/13 patients) IVF pregnancy rate in women ages 41-42 years old (Rice et al., 2015a)

2008 Study:

  • 60% (3/5 patients) natural pregnancy and live birth rate for women 35 or older in the natural study (Wurn et al., 2008)
    – a 42-year-old blocked tubes study participant had never been pregnant and had two blocked tubes for 10 years; she became pregnant naturally after therapy and delivered a healthy baby girl
    – the oldest natural infertility reversal reported to us was 43 years old when she gave birth

2004 Study:

  • 57% (3/7 patients) IVF clinical pregnancy rate among women 41 or older in the pre-IVF study (Wurn et al., 2004a)
    – a 43-year-old pre-IVF study participant had four unsuccessful pre-treatment IVFs, then became pregnant and had a live birth with her first post-treatment IVF
    – a 36-year-old pre-IVF study participant had three unsuccessful pre-treatment IVFs and one post-treatment, then became pregnant naturally after therapy and delivered a healthy baby girl

Sexual Function and Pain Level Improvements – General (2004)

  • 96% (22/23 patients) of sexual function study participants reported reduced sexual intercourse pain
  • 56% (13/23 patients) had improved or first-time orgasms
  • 65% (15/23 patients) had increased satisfaction
  • 70% (16/23 patients) had increased lubrication
  • 74% (17/23 patients) had increased arousal
  • 78% (18/23 patients) had greater or renewed desire (libido)
  • 91% (21/23 patients) had overall increased sexual function (Wurn et al., 2004b)

graph showing the results of a study monitoring intercourse pain and sexual function improvements

Sexual Function and Pain Level Improvements – Endometriosis (2011)

  • 50% (9/18 patients) of study participants reported reduced ovulation pain
  • 61% (11/18 patients) reported reduced menstrual pain
  • 80% (24/30 patients) reported reduced intercourse pain
  • 64% (9/14 patients) reported increased intensity and duration of orgasm
  • 71% (10/14 patients) reported increased desire (libido)
  • 86% (12/14 patients) reported increased arousal
  • 79% (11/14 patients) reported increased lubrication
  • 71% (10/14 patients) reported increased satisfaction
  • 93% (13/14 patients) reported improved overall sexual function (Wurn et al., 2011)

increase in sexual function for patients